In an in-vivo study by Kodack et al., it was observed that through the use of a combination of a HER2 inhibitor with an anti–VEGF receptor-2 antibody, trastuzumab, and lapatinib, tumor growth was significantly slowed in the brain, resulting in increased survival in a mouse model of HER2-amplified breast cancer brain metastasis using an orthotopic xenograft of BT474 cells [45]. Here, ERBB2 is linked to breast cancer.