VEGFA and central nervous system cancer: Because of the limited number of eligible studies, stratified analysis on the basis of genotyping method and Hardy-Weinberg equilibrium (HWE) in controls was only performed on rs3025039. A significant association between VEGFA polymorphism rs3025039 and glioma susceptibility was identified in HWE group under the allele contrast (OR = 1.211, 95% CI = 1.053–1.392, P = 0.007), recessive (OR = 2.451, 95% CI = 1.537–3.907, P < 0.001), and homozygous models (OR = 2.482, 95% CI = 1.554–3.964, P < 0.001) (Table 3).