The minor allele of VEGFA rs3025039 was related to a significantly increased glioma risk under the allele contrast (OR = 1.209, 95% CI = 1.088–1.343, P < 0.001), recessive (OR = 1.973, 95% CI = 1.489–2.615, P < 0.001), and homozygous models (OR = 1.982, 95% CI = 1.491–2.635, P < 0.001) (Figure 1A). Here, VEGFA is linked to central nervous system cancer.