Significant associations were observed between glioma risk and single nucleotide polymorphisms (SNPs) in several genes, including telomerase reverse transcriptase (TERT), regulator of telomerase elongation helicase 1 (RTEL 1), cyclin dependent kinase inhibitor 2A-cyclin dependent kinase inhibitor 2B (CDKN2A-CDKN2B), coiled-coil domain containing 26 (CCDC26), tumor protein p53 (TP53), epidermal growth factor receptor (EGFR), and pleckstrin homology-like domain family B member 1 (PHLDB1) [6–8]. The gene discussed is PHLDB1; the disease is central nervous system cancer.