In addition to ICI, ipilimumab has also been administrated with dacarbazine [13], the glycoprotein 100 (gp100) peptide vaccine [9], granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccine [14] or budesonide [15] for treating the patients with advanced melanoma. This evidence concerns the gene CSF2 and melanoma.