In our previous reports, we demonstrated that downregulation of miR-145, miR-200c, and miR-199b is significantly associated with PCa progression; in contrast, we found hypoxia-inducible factor (HIF-1α), which may be suppressed by miR-199b, was overexpressed in PCa and inhibited apoptosis via BCL2-xL transactivation [11, 16–18]. Here, HIF1A is linked to posterior cortical atrophy.