Our data demonstrated that miR-199a-5p is downregulated in PCa, but, in contrast to HIF-1α nuclear expression level, it alone was not significantly associated with patient survival, indicating miR-199a-5p was among many factors influencing HIF-1α level, which was a major determinant of tumor progression and patient survival in PCa. This evidence concerns the gene HIF1A and posterior cortical atrophy.