BNIP3 and neoplasm: Synchronous with the changes in HIF/BNIP3/BCL-xL/VEGF/CXCR4 upon artificial miR-199a-5p overexpression, PC-3 and DU145 cells showed reduced growth, invasiveness and tumor angiogenic ability (Figure 5A, 5B and 5C) but increased apoptosis (as assessed by the TUNEL assay; Figure 5D).