In both cell lines, the expression of two of the epithelial–mesenchymal transition (EMT) markers, including fibronectin and Snail, were detected to be inhibited by AKR7A3 overexpression (Figure 5C), which could partly explain the effects of AKR7A3 overexpression on migration and invasion of HCC cells. This evidence concerns the gene FN1 and hepatocellular carcinoma.