SOCS3 and colonic neoplasm: In addition, acetyl-STAT3 (K685) was suggested to crucial for promoter methylation of tumor suppressor genes such as STAT1, p53, SOCS3, SHP-1, and p16 (CDKN2A) in mouse embryonic fibroblasts, A2058 melanoma cell, and HCT116 colon cancer cell [7, 13].