Three patients had differing TP53 mutations in cfDNA-based and tumor tissue NGS: pan-545 (G389G in cfDNA, S261fs*2 in tumor), pan-594 (H193L and V272L in cfDNA, only V272L in tumor), and pan-598 (P278S in cfDNA, P153fs*28 in tumor). The gene discussed is TP53; the disease is neoplasm.