To establish that the TAM treatments were having some biological effect on the tumors (including their stroma) despite the TAM resistance of MCF7mutER(Y537S) tumor cells, we showed that the TAM injections caused an upregulation in tumor TGFβ-1 and VEGF-A protein expression (Supplement Figure S5), known to be part of an ER-independent TAM response [25–27]. This evidence concerns the gene VEGFA and neoplasm.