Consistent with our observations, reverse phase protein array analysis (RPPA) carried out by our group [71] comparing more than 150 proteins (including phosphorylated state when available) indicated that the expression of a distinct group of proteins including HIF1A, FOXO3, BCL2, TRP53, MAPK and STAT5 (phospho-Tyr694) was elevated in AML-derived BM-MSC (n = 106) compared to normal donor-derived BM-MSC (n = 71). This evidence concerns the gene HIF1A and acute myeloid leukemia.