In agreement with these data, CDK4 mRNA was up-regulated in BM-MSC from mice engrafted with MLL/ENL+FLT3-ITD Trp53 wt and MLL/ENL+FLT3-ITD Trp53-/- but not in BM-MSC from other leukemia-bearing mice. This evidence concerns the gene KMT2A and leukemia.