Interestingly, adipogenesis was also a signature present in BM-MSC exposed to MLL/ENL and MLL/ENL+FLT3-ITD Trp53-/- leukemia but not in BM-MSC from MLL/ENL+FLT3-ITD Trp53wt leukemia-bearing mice. Here, KMT2A is linked to leukemia.