We inoculated C57BL/6 mice with syngeneic primary murine leukemia cells null for Trp53 (Trp53-/-) and harboring one of the following human AML genotypes: AML1/ETO9a, MLL/ENL, or MLL/ENL+FLT3-ITD. This evidence concerns the gene KMT2A and acute myeloid leukemia.