Activation of NRF2 in BM-MSC exposed MLL/ENL+FLT3-ITD Trp53-/- was a key feature of this condition and opposite to BM-MSC challenged with MLL/ENL leukemia suggesting that this signature could be driven by FLT3-ITD but counteracted by p53 as it was not significant in the MLL/ENL+FLT3-ITD Trp53wt condition. The gene discussed is TP53; the disease is leukemia.