The pooled OR from 7 articles which include 736 MM and 73 normal bone marrow are presented in Figure 2A (odds ratios, OR=16.92, 95% confidence intervals, CI=5.86-48.87, p<0.00001), which demonstrates that the loss of p16 expression by hypermethylation plays critical role in the tumorigenesis of MM. Here, CDKN2A is linked to Miyoshi myopathy.