CDKN2A and Miyoshi myopathy: The pooled data from this meta-analysis indicate that 1) remarkably higher the p16 hypermethylation was detected in MM than that from normal bone marrow; 2) the p16 hypermethylation was also detected in MGUS, but remarkably less than that from MM; 3) MM patients in advanced MM do not show high levels of the p16 hypermethylation compared with those at early stage; 4) MM patients with the p16 hypermethylation had a lower survival rate than those without the p16 hypermethylation.