Compared to many other tumor types previously exposed to HDAC inhibitors in the Dent laboratory, e.g. breast cancer; liver cancer; pancreatic carcinoma; sarcoma; renal carcinoma; glioblastoma; the PDX and established mutant B-RAF melanoma isolates tested in our studies were highly sensitive to being killed by HDAC inhibitors as single agents at clinically relevant concentrations. This evidence concerns the gene PPIB and sarcoma.