In summary, this study reported that tumor suppressor role of RLIM in HCC, and presented evidence on the underlying mechanisms, whereby RLIM interacts with MIZ1 and c-MYC, regulating the transcription of p15 and p21 and influencing the proliferation and cell cycle progression in hepatic carcinogenesis. The gene discussed is CDKN2B; the disease is hepatocellular carcinoma.