MAPT and Alzheimer disease: Therefore, the goal of this study was to: i) verify if murine models of AD present similar structural alterations of the visual system, focusing on TgCRND8 mice, a well characterized model of AD [24-27, 37]; ii) detect eventual accumulation of Aβ peptides or Tau in the eye of TgCRND8 mice; iii) study the molecular mechanisms leading to structural changes in the retina, focusing on JNK signalling pathway; iv) test the protective role of D-JNKI1, a specific JNK inhibitors, in the eye.