FLT3 and cancer: Crenolanib is known to potently inhibit mutant-FLT3 D835 and -PDGFR D842 isoforms in vitro and is currently being investigated in several clinical trials for the treatment of FLT3 D835- and PDGFR D842-associated cancers [11, 12], (clinicaltrials.gov; e.g. NCT01243346, NCT01522469, NCT02400281).