Importantly, potency of crenolanib to inhibit cellular proliferation as well as to induce apoptosis of the engineered Ba/F3 cell strains (harboring KIT D816V, KIT D816Y or FLT3 ITD) revealed strong correlation with the corresponding tumor cell lines (HMC1.2, p815 or MOLM14, respectively). The gene discussed is FLT3; the disease is neoplasm.