Notably, sensitivity profiles for crenolanib obtained in the Ba/F3 isogenic cell model corresponds to phosphoprotein sensitivities in the native mastocytosis cell lines HMC1.2 (harboring KIT D816V, Figure 4A) and p815 (harboring murine Kit D814Y, which is homologous to human KIT D816Y, Figure 4B). Here, KIT is linked to mastocytosis.