ESRP1 and familial pancreatic carcinoma: ESRP1 down-regulation is able to promote EMT in several solid cancers, such as pancreatic cancer and breast cancer [24, 29, 30], but further experiments will be necessary to clarify the conundrum of functions of miR-23a in inducing of pancreatic cancer cell EMT and metastasis by targeting ESRP1.