In AML cells from promyelocytic (M3) and monocytic (M5) lineages, we saw that glucose was used mainly to sustain cell proliferation probably through Pentose Phosphate Pathway (PPP), as seen HL60 (promyelocytic) and THP1 (monocytic) cells incorporate carbons from 13C-glucose in nucleotides, in the presence of VEGF (Figure 2A and 2B). The gene discussed is VEGFA; the disease is acute myeloid leukemia.