Metabolic adaptation involves an orchestrated remodelling of metabolic intervenients and in lactate metabolism the most important elements are monocarboxylate transporters (MCTs) [9, 10] - in cancer MCT1 and MCT4 seem to be the most relevant [11, 12, 39]; and lactate dehydrogenases (LDH), which are able to convert lactate and pyruvate in both ways and have even been considered as putative therapeutic targets in cancer [40, 41]. This evidence concerns the gene SLC16A1 and cancer.