Considering the significant increases in the immunosuppressive populations (Tregs, MDSCs, and M2 TAMs) as a result of tumoral B7x expression, we decided to go further and obtain a snapshot of these subsets in relation to effector cells (CD4+, CD8+, and CD8+ Tetramer+ cells) to understand how the dynamic between these cells changes in the tumor microenvironment. The gene discussed is CD4; the disease is neoplasm.