Current literature suggests that the secretion of cytokines IL-10 and IFNγ from TAMs can up-regulate B7x on lung cancer and hematological malignancies like Non-Hodgkin Lymphoma (NHL) [27, 28], however our studies did not confirm this after assaying several different human and murine tumors. Here, VTCN1 is linked to non-Hodgkin lymphoma.