Also, utilizing the pulmonary experimental metastasis model with the colonic murine tumor cell line, CT26, overexpressing B7x, we revealed a detailed phenotypic description of the adaptive and innate immune cell infiltrate as a result of tumor-expressed B7x and demonstrate how it contributes to M2 macrophage polarization, along with regulatory T cell (Tregs) and antigen-specific CD8 T cell exhaustion. Here, CD8A is linked to neoplasm.