TYMS and non-small cell lung carcinoma: In addition, the TS protein expression was also noted to be elevated in six inherently pemetrexed resistant NSCLC cell lines CALU6, H522, H650, H661, H820, H1838 relative to pemetrexed-sensitive cell lines H460 and H1299 (Supplementary Figure 1) with IC50 measurements of (Supplementary Figure 2).