PRKAB1 and metabolic dysfunction-associated steatotic liver disease: Studies have revealed that various signaling pathways such as nuclear factor κB (NF-κB), AMP-activated protein kinase (AMPK), Toll-like receptor (TLR) and phosphatidylinositol 3- kinase/protein kinase B (PI3K/Akt) are involved in the progress of NAFLD.