CXCL8 and cancer: Canonical pathway analysis showed that the upregulated pathways following ectopic expression of Hic-5 in A2780s cells were related to IL-8 signaling, PI3K signaling, EIF2 signaling, Wnt/Ca+ pathway, Wnt/β-catenin signaling, p38 MAPK signaling, and ILK signaling pathways, all involved in EMT induction in cancer (Figure 10A).