Consistent with our previous data in vitro, tumor specimens derived from sh-S1 cells showed very low staining intensity for the Hic-5 gene, while these tumors stained strongly for E-cadherin when compared with Ctrl SKOV3 derived tumors, whereas N-cadherin was only present following the injection of Ctrl cells (Figure 12B). This evidence concerns the gene CDH2 and neoplasm.