Combined with a comprehensive literature research for recurrent gene abnormalities in MDS [20-22, 27], especially for genes associated with prognosis, we generated a final candidate panel comprsing 11 genes (EZH2, TET2, ASXL1, TP53, DNMT3A, RUNX1, ETV6, SRSF2, U2AF1, IDH1, IDH2) for targeted sequencing in MDS. The gene discussed is TP53; the disease is myelodysplastic syndrome.