One of these inhibitory molecules is programmed death-ligand 1 (PD-L1; also known as B7-H1 or CD274) that is expressed on tumor cells, which then binds to programmed death 1 (PD-1) that is expressed on T-cells, B-cells, dendritic cells, and natural killer T-cells to suppress anti-cancer immunity and to enable neoplastic growth [3]. This evidence concerns the gene CD274 and cancer.