CDH1 and gastric cancer: Although MSI-H gastric cancers are hyper-mutated, MSS gastric cancers also possess a high frequency of genetic alterations such as CDH1, RHOA, HER2, EGFR, VEGFR, MET, and FGFR2, all of which may directly or indirectly affect the MAPK and PI3K/Akt survival pathways [40, 41].