XPO1 and neoplasm: In addition to the induction of miR-145 in PDAC cells, RNAi of XPO1 or selinexor treatment increased the expression of other tumor suppressive miRNAs including let-7d, miR-34c and miR-320 (Figure 6A-6C), and decreased the expression of oncogenic miR-205 (Figure 6D).