By utilizing two different cancer cell line models (breast – MCF7, SKBR3 and non-small cell lung cancer – H1299), we were able to show, in our control experiments, that cells expressing the conformational mutant (p53 R175H) and contact mutant (p53 R273H) developed chemoresistance to DNA damage chemotherapeutic treatment more efficiently than expressing the WT p53 (Supplementary Figures 2 and 3). Here, TP53 is linked to non-small cell lung carcinoma.