Though a recent study characterizing tumoral expression of the ligand for programmed cell death protein-1 (PD-1, or CD279), PD-L1, in MPNST tumors reported no correlation with patient outcomes[15], PD-1-positive lymphocyte infiltration and tumoral PD-L1 expression have previously been reported to correlate with decreased overall and event-free survival rates for soft tissue sarcomas including MPNST [16]. This evidence concerns the gene CD274 and malignant peripheral nerve sheath tumor.