The Univariate Cox Regression analysis showed that in addition to gender, current smoking status, (PS) , N stage, M stage and organ metastases counts, abnormal nutrition-based hematological indexes (albumin), inflammatory-immune based hematological indexes (NLR and NLMR), hemostasis-based hematological indexes (D-dimer, Fg, FDP and PDM), and commixed hematological indexes (SII, PNI, NLFDPA, NLFgA, and NLDA) were negatively associated with the prognosis in patients with NSCLC. The gene discussed is ALB; the disease is non-small cell lung carcinoma.