Furthermore, MMP-2, MMP-9 and VEGF hypoexpression and BRMS1 hyperexpression accounted for the anti-invasion and anti-metastasis effects of ING5 because the former three promote the degradation of extracellular matrix and angiogenesis [20] and BRMS1 reduces the metastatic potential of human breast cancer and melanoma cells as a component of the mSin3a family of histone deacetylase complexes [21]. This evidence concerns the gene VEGFA and melanoma.