Moreover, we showed that miR-143 regulates cancer glycolysis in ZD-induced esophageal neoplasia by targeting HK2 (Figure 3), a result consistent with reports for lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, breast cancer, and prostate cancer [36-38, 62, 63]. The gene discussed is HK2; the disease is hereditary clear cell renal cell carcinoma.