To further validate this phenotypic change, two basal-like/triple-negative breast cancer (TNBC) cell lines, MDA-MB-231 and MDA-MB-468, and two luminal/Estrogen Receptor positive (ER+) cell lines, T47D and MCF-7, were transfected with non-targeting scramble or LSD2-specific siRNA. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.