Number of tender and number of swollen joints, number of tender fibromyalgia points, ESR, DAS28, weekly dose of MTX, serum levels of IGF1, leptin, adiponectin, resistin, visfatin, IL-6, IL-1β, percentage of the body fat, and mRNA levels of IGF1R, STAT3, TLR4, AKT1, RETN, RELA in WAT were introduced as independent variables in the first step of the model. This evidence concerns the gene LEP and fibromyalgia.