Thus, we propose that the suppression of hippocampal GSK-3β phosphorylation induced by the SM70EE-enhanced BDNF/PI3K/Akt signaling pathway contributes to the inhibition of APP processing by downregulating BACE1 to ameliorate the cognitive disorders induced by an I.C.V. injection of Aβ1–42 (Figure 5). Here, BACE1 is linked to cognitive disorder.