ESR1 and multiple sclerosis: Moreover, ER agonists activated PI3K/Akt/mTOR signalling in oligodendrocytes to promote remyelination in a mouse model of multiple sclerosis (MS) [70,71], and the up-regulation of the membrane ERα was associated with functional signals that were compatible with autophagic cytoprotection of neuronal cell line SH-SY5Y.