Using the overlay diseases and functions tool in the IPA software, we disclosed ADAMTS12, BDKRB1, BDKRB2, BMP1, FGF2, FOXO1, KCTD20, NOTCH4, PPARG, TGFB1 and miR-146a-5p to be associated with “rheumatic disease” and “inflammation of joint” in network 1, as indicated by purple frames in Figure 6. The gene discussed is NOTCH4; the disease is rheumatic disorder.