AKAP12 and rheumatoid arthritis: As shown in Table 3, the up-regulated LRRC15 in RA osteoblasts was found up-regulated in four out of the five arrays of synovial tissues; the down-regulated AKAP12 in RA osteoblasts was found down-regulated in four out of the five arrays of synovial tissues; and up-regulated in one array of synovial macrophages.