The rationale for the current study was that on the one hand FGF23 has been robustly associated with an increased cardiovascular risk in CKD patients, providing a rationale for prospective intervention studies targeting plasma FGF23, and on the other hand our recent finding that higher n-3 fatty acid intake is independently associated with lower plasma C-terminal FGF23 levels, albeit in a different patient population (renal transplant recipients) [13]. The gene discussed is FGF23; the disease is chronic kidney disease.