Overexpression of hsa-miR-107 in glioma cells suppressed their proliferation and their migratory, invasive, and angiogenetic capabilities by targeting p53 [50], Notch-2 [48, 49], CDK6 [50], matrix metalloproteinase (MMP)-12 [48], and vascular endothelial growth factor (VEGF) [51]. This evidence concerns the gene MMP12 and central nervous system cancer.