MGMT and central nervous system cancer: Histology combined with new molecular techniques is now the gold standard in glioma diagnostics [3]; as several molecular alterations have proved to be important as diagnostic and prognostic tools e.g. mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) genes and the promoter of telomerase reverse transcriptase (TERT) as well as methylations of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter [3, 4].