In the Glioma Pathway, genes involved in ErbB, mTOR, and MAPK signaling pathways as well as genes important for cell cycle were found to be most likely regulated by the miRNAs e.g. Kirsten rat sarcoma viral oncogene homolog (KRAS) (miR-3125, miR-548x-3p, miR-548x-5p), phosphatase and tensin homolog (PTEN) (miR-548x-3p, miR-548x-5p), V-akt murine thymoma viral oncogene homolog 3 (AKT3) (miR-107, miR-548x-3p), and cyclin-dependent kinase 6 (CDK6) (miR-107, miR-548x-3p) (Fig 3D). This evidence concerns the gene PTEN and central nervous system cancer.