Similarly to Vav1−/− T-ALL (Figures 2 and S3), we found that VAV1−/− Jurkat cells exhibit increased amounts of ICN1 protein (Figures 4A and S4A) as well as of HES1 and NOTCH1 transcripts (Figure 4B) when compared with controls. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.