We found that the ectopic expression of Vav1WT leads to decreased ICN1 levels (Figures 8D, 8E, and S8D), reduced HES1 promoter activity (Figures 8F and S8E), reduced proliferation (Figures 8G, 8H, and S8F), and increased apoptosis (Figures 8I and S8F) in HPB-ALL cells. This evidence concerns the gene HES1 and acute lymphoblastic leukemia.