These analyses indicated that the TLX+ T-ALL clinical subtype cases consistently showed a statistically significant reduction in the abundance of the VAV1 mRNA (Figures 7A–7C, S7A, and S7B) as well as high transcriptional similarity to a diagnostic signature composed of gene probes commonly deregulated in Vav1−/− and Zfp36l1−/−;Zfp36l2−/− T-ALL cells (Figures S7C–S7E). Here, VAV1 is linked to acute lymphoblastic leukemia.