Strikingly, these temporal differences in flow abnormalities in hemizygote subjects concur with the period of brain development with highest metabolic demand (Kuzawa et al., 2014) in a region with lower cerebral blood flow relative to the density of axonal packing (Giezendanner et al., 2016) and greatest susceptibility for conversion to CALD (Eichler et al., 2007; Moser et al., 2007; Berger et al., 2014), indicating a selective, age-dependent effect of the ABCD1 deficiency state upon the white matter regions most susceptible to cerebral demyelination. Here, ABCD1 is linked to Peripheral demyelination.