At the same time, miR-199a-1, miR-199-2, mir-125b and miR-125b-5P are negatively regulated by the transcription factor NFKB1, which regulates genes associated with the pathogenesis of SLE such as TNF, IFNG, C3 and CD40LG [44]. This evidence concerns the gene C3 and systemic lupus erythematosus.