CK-19 also plays a key role in HCC with the expression of invasion-related/metastasis-related markers (VASP, LAMB1, PDGFRA), biliary marker (CD133, GSTP1, JAG1) and members of microRNA family 200, especially in PDGFRA-LAMININ B1-CK-19 cascade [29, 30]. The gene discussed is JAG1; the disease is hepatocellular carcinoma.