TACC3 and cancer: Second, TACC3 expression was associated with the expression of stem cell transcription factors, including Bmi-1, c-Myc, and Nanog, and the upregulation of TACC3 promoted tumor stem cell-like capabilities in hepatocellular carcinoma [13]; cancer stem cells can maintain themselves by self-replication to create additional daughter cells in their milieus [29].