K14-driven expression of HPV16 E6 and E7 results in a systemic epidermal dysplasia and low penetrance oncogenesis [14]; however, by combining this with the 4-NQO model of chemical carcinogenesis, which induces high penetrance formation of multifocal papilloma that can progress to malignancy [15], the rate of progression can be significantly advanced within the oral cavity (and esophagus) [16]. The gene discussed is KRT14; the disease is papilloma.