On the contrary, a clinical study by Ren et al. shows that TIM-3 expression on monocytes was significantly elevated among sepsis patients as compared to severe sepsis, septic shock and control patients; and soluble TIM-3 (sTIM-3) levels in the plasma of septic shock group was higher than just sepsis or severe sepsis groups, the levels of which correlated with eventual non-survivors [60]. Here, HAVCR2 is linked to Sepsis.