HAVCR2 and Sepsis: A study by Zhao et al. using CLP model of sepsis demonstrated that blocking TIM-3 signaling with soluble TIM-3-Immunoglubulin (sTIM-3-IgG) resulted in exacerbation of sepsis induced macrophage pro-inflammatory responses and lymphocyte apoptosis during acute phase of sepsis, and enhanced anti-inflammatory phenotype for macrophages and CD4+ T cells during late phase of sepsis [63].