CNPY2 was first revealed as a vital modulator that enhances neurite outgrowth in neuroblastoma and PC12 cells and pro-motes cell migration in rat C6 glioma cells by phospho-rylating and preventing ubiquitination of myosin regula-tory light chain (MRLC) [13,14]. The gene discussed is CNPY2; the disease is central nervous system cancer.