Thus, a reduction of these interneuron subclasses together with the compromised presynaptic function due to CLN3 dysfunction may lead to disinhibition of amygdala networks and finally be the pivotal mechanism explaining decreased cued learning performance and increased anxiety-levels in Cln3Δex1-6 mice (Tovote et al., 2015; Nuss, 2015). The gene discussed is CLN3; the disease is Anxiety.