These findings were validated by a large multicenter retrospective study of 732 patients (33), in which Soria and colleagues found that HER-2 was overexpressed in 35.6% of patients and linked to pathological characteristics, such as more advanced T stage, presence of lymph node metastasis, high-grade tumor, tumor necrosis, and lympho-vascular invasion. Here, ERBB2 is linked to neoplasm.