MYC and melanoma: WP1130 (degrasyn, (2E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[1S-phenylbutyl]-2-propenamide) (Fig. 3A) is a partially selective DUB inhibitor initially identified as a stabilizer of Bcr/Abl in chronic myelogenous leukemia [103] and a negative regulator of MYC in melanoma [104].