Both Caprin-1 and Syncrip showed significant upregulation in C9-ALS iPSC-MN compared to controls, while RBMS3 showed decreased expression in the two SALS lines compared to controls, recapitulating results obtained in total spinal cord, although a larger sample size is needed to confirm these findings. The gene discussed is CAPRIN1; the disease is amyotrophic lateral sclerosis.