Mutations or variants in the genes of 11 RNA-binding proteins (RBPs) or proteins that function in RNA processing are associated with ALS, including TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, SETX, ELP3, ATXN2, ANG, SMN1, and SMN2 [7, 45, 52]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.