SYNCRIP and amyotrophic lateral sclerosis: Purkinje cells displayed weak Syncrip immunostaining in control subjects (89% of neurons displayed negative-to-weak immunoreactivity; Fig. 3b), while neuronal staining was significantly increased in both the C9-ALS and SALS groups (58 and 64% of neurons were associated with medium-to-strong Syncrip staining in each subject group, respectively).