SRSF2 (also known as SC-35, ranked 5) is a nuclear speckle component that potentially interacts with TDP-43, FUS and the G4C2 repeat expansion and has been shown to co-localize with 34% of C9 antisense RNA foci in cerebellar Purkinje cells of C9-ALS patients [12]. This evidence concerns the gene SRSF2 and amyotrophic lateral sclerosis.