The known set included all 11 known RBPs mutated in ALS identified prior to 2016 (TDP-43, FUS, Ataxin-2, hnRNPA1, hnRNPA2B1, Senataxin, Angiogenin, TAF15, GLE1, Matrin-3 and ARHGEF28). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.