Screening for AD-associated genes in a large Chinese cohort demonstrated rather weak association with the most significant hits in the Caucasian analyses and identified strong associations with SNPs in the gene encoding the complement regulator factor H (CFH); the two strongest associating SNPs, rs1061170 and rs800292, are both coding variants causing respectively a H402Y and a I62V change in the protein [71] (Fig. 3). This evidence concerns the gene CFH and Alzheimer disease.