CIRBP and cancer: Further studies exploring the molecular mechanism of CIRP by using genome-wide expression microarrays in CIRP knockdown cells and pathway analyses of differentially expressed genes in CIRP-deficient cells and control cells showed five enriched pathways, namely, focal adhesion, MAPK, Wnt, apoptosis and cancer-related signaling pathways, which may be the central pathway networks regulated by CIRP [43].