CIRP is upregulated in a subgroup of patients with solid cancers including colon cancer, prostate cancers, central nervous system-related tumors and liver-pancreas carcinomas, in which, CIRP is expressed mainly in the cytoplasm [63], suggesting that CIRP upregulation and translocation may have biological significance in human tumors. This evidence concerns the gene CIRBP and malignant colon neoplasm.