Recently, CIRP is found to be highly expressed in the bronchi in patients with chronic obstructive pulmonary diseases and in vitro study found that CIRP contributed to cold stimulation-induced expression of inflammatory cytokines and mucin in human airway epithelial cells by activating ERK and NF-κB signaling pathway [95,96] suggesting that CIRP plays an important role in chronic airway inflammation diseases and mucus overproduction. This evidence concerns the gene CIRBP and chronic obstructive pulmonary disease.