TARDBP and Alzheimer disease: We also have observed ∼35 and ∼25 kDa TDP-43 fragments in platelet lysates obtained from AD patients in early stages of this work (data not shown); we thought that they could represent the degradation products of TDP-43 due to either storage of samples at -80°C for extended period of time or the degradation could be due to the old age of the subjects (Figure 2C).