We chose platelets for identifying and measuring both total and phosphorylated TDP-43 protein derivatives in AD for the following reasons: platelets are easy to repeatedly obtain acessible human tissue  from the patients with minimal distress; their life span is short (7–10 days) [36] which will reflect dynamic changes on phosphorylated TDP-43; it was reported that platelets transiently open the blood–brain barrier (BBB) [37]. Here, TARDBP is linked to Alzheimer disease.