An antiphospho (S409/410-2) TDP-43 antibody (ProteinTech Cat# 22309-1-AP) was identified as a potential antibody that discriminates AD platelet lysate phospho-TDP-43 profile from that of ALS (negative disease control) (Figure 3A) and from that of nonsymptomatic, otherwise healthy age-matched subjects (Figure 3B). Here, TARDBP is linked to amyotrophic lateral sclerosis.